Shiming Chen, PhD

Professor of Ophthalmology and Visual Sciences,

Office Phone: (314) 747-4350

Fax: (314) 747-4211

Email: Chen@vision.wustl.edu

Click here for Dr. Chen lab website

Education

  • B.S. Biology, Capital Normal University, Beijing, China., 1978-1982
  • M.S. Biochemistry, Beijing Medical University, Beijing, China Mentor: Pei-Nan Liu, 1982-1984
  • Ph.D. Biochemistry and Molecular Biology, State University of New York-Upstate Medical University, Syracuse, NY. Mentor: Robert W. West, Jr., 1986-1992

Training

  • Postdoctoral fellow, Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD. Mentor: Donald J. Zack , 1992-1998

Honors and Awards

  • National Award for Advanced Science and Technology, China, 1986
  • NRSA postdoctoral fellowship award, NIH., 1994
  • The Albert L. Lehninger Prize for Postdoctoral Investigation, Johns Hopkins University School of Medicine, Baltimore, MD, 1998
  • Career Development Award, Research to Prevent Blindness., 1998
  • Sybil B. Harrington Scholar Award, Research to Prevent Blindness., 2003
  • Lew R. Wasserman Merit Award, Research to Prevent Blindness., 2009
  • Ophthalmology Research Teacher of the Year, Washington University., 2009

Selected Publications

  1. Chen J, Wang Q, Chen S, Wickline SA, Song SK: In vivo diffusion tensor MRI of the mouse retina: A noninvasive visualization of tissue organization. NMR in Biomed 2010 Oct 7. [Epub ahead of print]. PMID: 20931570
  2. Onishi A, Peng G-H, Chen S, Blackshaw S: Control of mammalian cone photoreceptor differentiation by Pias3-dependent SUMOylation. Nature Neuroscience 2010, 13:1059-1065.
  3. Onishi A, Peng GH, Poth EM, Lee DA, Chen J, Alexis U, de Melo J, Chen S, Blackshaw S: The orphan nuclear hormone receptor ERR{beta} controls rod photoreceptor survival. Proc Natl Acad Sci U S A. 2010, 107:11579-11584. [Epub 2010 June 4].
  4. Onishi A*, Peng G-H*, Hsu C, Alexis U, Chen S#, Blackshaw S# $: Pias3-dependent SUMOylation directs rod photoreceptor development. Neuron 2009, 61: 234-246. *Equal-contributing first authors. #Co-corresponding authors. This article was selected for Recommended Reading by Faculty of 1000 Biology (http://www.f1000biology.com/article/id/1147989); previewed by Carole LaBonne “SUMO Weighs In on a Photoreceptor Finish” Dev Cell 2009, 16:165-166; highlighted by Leonie Welberg “Development: Staying on course with PIAS3” Nat Rev Neurosci 2009, 10: 171.
  5. Escher P, Gouras P, Roduit R, Tiab L, Bolay S, Delarive T, Chen S, Tsai C-C, Hayashi M, Zernant J, Merriam JE, Mermod N, Allikmets R, Munier FL and Schorderet DF: Mutations in NR2E3 can cause dominant or recessive retinal degenerations in the same family. Human Mutation 2009, 30:342-351.
  6. Mali RS, Peng G-H, Zhang X, Dang L, Chen S and Mitton KP: FIZ1 Is part of the regulatory protein complex on active photoreceptor-specific gene promoters in vivo. BMC Mol Biol. 2008, 9:87. doi:10.1186/1471-2199-9-87.
  7. Hennig AK, Peng G-H and Chen S: Regulation of photoreceptor gene expression by Crxassociated transcription factor network. Brain Res. 2008, 1192:114-133.
  8. Young JE, Gouw L, Propp S, Sopher BL, Taylor J, Lin A, Hermel E, Logvinova A, Chen SF, Chen S, Bredesen DE, Truant R, Ptacek LJ, La Spada AR, Ellerby LM: Proteolytic cleavage of ataxin-7 by caspase-7 modulates cellular toxicity and transcriptional dysregulation. J. Biol. Chem. 2007, 282:30150-30160. PMCID: PMC2276662
  9. Peng G-H and Chen S: Crx activates opsin transcription by recruiting HAT-containing coactivators and promoting histone acetylation. Hum. Mol. Genet. 2007, 16:2433-2452. (Cover article).
  10. Dorval KM, Bobechko BP, Fujieda H, Chen S, Zack DJ and Bremner R: Chx10 targets a subset of photoreceptor genes. J. Biol. Chem. 2006, 281:744-751.

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