Vladimir Kefalov, PhD

Professor, Department of Ophthalmology & Visual Sciences

Office Phone: (314) 362-4376

Fax: (314) 747-9046

Email: kefalov@vision.wustl.edu

Click here for Dr. Kefalov lab website


  • Postdoctoral Fellow, Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, 1999
  • Ph.D. in Cellular Biophysics, Department of Physiology, Boston University School of Medicine, Boston, Massachusetts, 2005


  • Cell & Developmental Biology of Xenopus course at Cold Spring Harbor Laboratory, Cold Spring Harbor, New York., 2005
  • Methods in Computational Neuroscience course at the Marine Biological Laboratory, Woods Hole, Massachusetts., 1999
  • Research Technician: Visual Perception Group, Institute of Human Physiology, Bulgarian Academy of Sciences, Sofia, Bulgaria., 1990-1992

Honors and Awards

  • Research to Prevent Blindness Career Development Award, 2006
  • FASEB Award for talk presentation (Biology and Chemistry of Vision research conference)., 2005
  • Boston University Student Achievement Day - First prize., 1999
  • Boston University Student Research Fellowship - First prize., 1998
  • Boston University Student Achievement Day - Second prize., 1998

Selected Publications

  1. Deng, W., Sakurai, K., Liu, J., Dinculescu, A., Li, J., Pang, J., Min, S., Chiodo, V., Boye, S., Chang, B., Kefalov, V.J., and Hauswirth, W. (2009). Functional interchangeability of rod and cone transducin α-subunits. Proc Natl Acad Sci USA 106:17681-17686.
  2. Wang, J. and Kefalov, V.J. (2009). An alternative pathway mediates the mouse and human cone visual cycle. Current Biology 19:1665-1669.
  3. Yamashita T., Liu J., Gao J., LeNoue S., Wang C., Kaminoh J., Bowne S.J., Sullivan L.S., Daiger S.P., Zhang K., Fitzgerald M.E. Kefalov V.J., Zuo J. (2009). Essential and synergistic roles of RP1 and RP1L1 in rod photoreceptor axoneme and retinitis pigmentosa. J. Neurosci. 29:9748-60.
  4. Wang, J., Estevez, M.E., Cornwell, M.C., and Kefalov, V.J. (2009). Intra-retinal visual cycle required for rapid and complete cone dark adaptation. Nature Neuroscience 12:295-302. (Journal Cover)
  5. Fu*, Y., Kefalov*, V.J., Luo* D.-G., Xue*, T., and Yau, K.-W. (2008). Quantal noise from human red cone pigment. Nature Neuroscience 11(5):565-571.
  6. Shi G., Yau K.-W., Chen J., Kefalov V.J. (2007). Signaling properties of a short-wave cone visual pigment and its role in phototransduction. J. Neurosci 27:10084-93.
  7. Kefalov, V.J., Estevez, M. E., Kono, M., Goletz, P. W., Crouch, R. K., Cornwall, M. C., and Yau, K.-W. (2005). Breaking the covalent bond - a pigment property that contributes to desensitization in cones. Neuron 46, 879-890.
  8. Kefalov*, V.J., Fu*, Y., Marsh-Armstrong, N., and Yau, K.-W. (2003). Role of visual pigment properties in rod and cone phototransduction. Nature. 425, 526-531.
  9. Kefalov, V.J., Crouch, R.K., and Cornwall, M.C. (2001). Role of noncovalent binding of 11-cis-retinal to opsin in dark adaptation of rod and cone photoreceptors. Neuron 29, 749-55.
  10. Kefalov, V.J., Cornwall, M.C., and Crouch, R.K. (1999). Occupancy of the chromophore binding site of opsin activates visual transduction in rod photoreceptors. J Gen Physiol 113, 491-503.

Click to view all Dr. Kefalov Publications

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