Alan Shiels, PhD

Associate Professor , Department of Ophthalmology and Visual Sciences, & Department of Genetics

Office Phone: (314) 362-1637
Lab: (314) 362-1642

Fax: (314) 362-1646

Email: Shiels@vision.wustl.edu

Click here for Dr. Shiels lab website

Education

  • BSc Biological Sciences, Faculty of Science and Engineering, Manchester Polytechnic, Manchester, U.K., 1974-1977
  • PhD Biochemistry, Department of Child Health, St. George’s Hospital Medical School University of London, U.K., 1977-1983

Training

  • Postdoctoral Research Associate, Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL, U.S.A., 1983-1985
  • Postdoctoral Research Associate, Department of Biochemistry, University College, London, U.K., 1985-1987

Honors and Awards

  • The National Foundation for Eye Research, Cataract Research Award, 2001

Selected Publications

  1. Shi Y, Barton K, Petrash JM, Shiels A, Bassnett S. The stratified syncytium of the vertebrate lens. J Cell Sci 2009; 122:1607-1615.
  2. Lee AY, Raya AK, Kymes S, Shiels A, Brantley MA. Pharmacogenetics of Complement Factor H (Y402H) and treatment of exudative age-related macular degeneration with ranibizumab. Br J Ophthalmol (BJO) 2009; 93:610-613.
  3. Brantley MA, Edelstein SL, King JM, Plotzke M, Apte RS, Kymes SM, Shiels A. Association of Complement Factor H and LOC387715 genotypes with response of exudative age-related macular degeneration to photodynamic therapy. Eye (Lond) 2009; 23:626-631.
  4. Shiels A, Bennett TM, Knopf HLS, Maraini G, Li A, Jiao X, Hejtmancik JF. The EPHA2 gene is associated with cataracts linked to chromosome 1p. Mol Vis 2008; 14:2042-2055.
  5. Brantley MA, Fang AM, King JM, Tewari A, Kymes SM, Shiels A. Association of Complement Factor H and LOC387715 genotypes with response of exudative AMD to intravitreal bevacizumab. Ophthalmology 2007; 114:2168-2173.
  6. Shiels A, Bennett TM, Prince JB, Tychsen L. X-linked idiopathic infantile nystagmus associated with a missense mutation in FRMD7. Mol Vis 2007; 13:2233-2241.
  7. Shiels A, Bennett TM, Knopf HLS, Yamada K, Koh-ichiro Y, Niikawa N, Shim S, Hanson PI. CHMP4B, a novel gene for autosomal dominant cataracts linked to chromosome 20q. Am J Hum Genet (AJHG) 2007; 81:596-606.
  8. Brantley MA, Edelstein SL, King JM, Apte RS, Kymes SM, Shiels A. Clinical phenotypes and treatment outcomes associated with the CFH Y402H variant in AMD. Am J Ophthalmol (AJO) 2007; 144:404-408.
  9. Shiels A, Hejtmancik JF. Genetic origins of cataract. Arch Ophthalmol 2007; 125:165-173.
  10. Shiels A, King JM, Mackay DS, Bassnett S. Refractive defects and cataracts in mice lacking lens intrinsic membrane protein-2. Invest Ophthal Vis Sci (IOVS) 2007; 48:500-508.

Internal Links

DOVS Portal

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