Carla J. Siegfried, MD

Jacquelyn E. and Allan E. Kolker, MD Distinguished Professor of Ophthalmology

Patients Seen At: (314) 362-3937 (Eye Center, Center for Advanced Medicine)
(314) 996-3300 (Medical Building Two, Barnes-Jewish West County Hospital, 10 Barnes West Drive, Suite 201)

Fax: (314) 362-3725 (Eye Center, Center for Advanced Medicine)
(314) 996-3490 (Medical Building Two, Barnes-Jewish West County Hospital, 10 Barnes West Drive, Suite 201)


Click here for Dr. Siegfried lab website


  • B.A. Biology: University of Missouri, Kansas City, 1989
  • Medical School: University Of Missouri, Kansas City School of Medicine, Kansas City, 1989


  • Residency: Ophthalmology, University of Illinois Eye and Ear Informary, Chicago, Illinois, 1993
  • Fellowship: Glaucoma, Northwestern University, Chicago, Illinois, 1994

Licensure and Board Certification

  • Ophthalmology -- Certified

Honors and Awards

  • Listed in Best Doctors in America, 2007-2013 (Best Doctors, Inc.)
  • AAO Secretariat Award, 2012
  • AAO Achievement Award, 2008

Selected Publications

  1. Beebe DC, Shui YB, Siegfried CJ, Holekamp NM, Bai F. Preserve the (intraocular) environment: the importance of maintaining normal oxygen gradients in the eye. Jpn J Ophthalmol. 2014 May;58(3):225-31.
  2. Netland PA, Sarkisian SR Jr, Moster MR, Ahmed II, Condon G, Salim S, Sherwood MB, Siegfried CJ. Randomized, prospective, comparative trial of EX-PRESS glaucoma filtration device versus trabeculectomy (XVT study). Am J Ophthalmol. 2014 Feb;157(2):433-440.e3.
  3. Nguyen A, Shui YB, Zhang Q, Beebe DC, Siegfried CJ. Aqueous humor oxygen measurements. J Glaucoma. 2013 Oct-Nov;22(8):e23-4
  4. Kymes SM, Lambert DL, Lee PP, Musch DC, Siegfried CJ, Kotak SV, Stwalley DL, Fain J, Johnson C, Gordon MO. "The development of a decision analytic model of changes in mean deviation in people with glaucoma: the COA model." Ophthalmology. 2012 Jul;119(7):1367-74.
  5. Siegfried CJ, Shui YB, Holekamp NM, Bai F, Beebe DC. "Racial differences in ocular oxidative metabolism: implications for ocular disease." Arch Ophthalmol. 2011 Jul;129(7):849-54.
  6. Siegfried CJ, Shui YB, Holekamp NM, Bai F, Beebe DC. "Oxygen distribution in the human eye: relevance to the etiology of open-angle glaucoma after vitrectomy." Invest Ophthalmol Vis Sci. 2010 Nov;51(11):5731-8.
  7. Falkenberry SM, Siegfried CJ. "Endocyclophotocoagulation." Middle East Afr J Ophthalmol. 2009 Jul;16(3):130-3.
  8. Shui YB, Holekamp NM, Kramer BC, Crowley JR, Wilkins MA, Chu F, Malone PE, Mangers SJ, Hou JH, Siegfried CJ, Beebe DC. "The gel state of the vitreous and ascorbate-dependent oxygen consumption: relationship to the etiology of nuclear cataracts." Arch Ophthalmol. 2009 Apr;127(4):475-82.
  9. Lee BS, Kymes SM, Nease RF Jr, Sumner W, Siegfried CJ, Gordon MO. "The impact of anchor point on utilities for 5 common ophthalmic diseases." Ophthalmology. 2008 May;115(5):898-903.e4

Click to view all Dr. Siegfried Publications

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