Selected Publications:
For complete list on PubMed, click here.
Delston RB, Harbour JW. Rb at the Interface Between Cell Cycle and Apoptotic Decisions. Curr Mol Med 2006; 6: 713-718.
Onken MD, Worley LA, Davila RM, Char DH, Harbour JW. Prognostic testing in uveal melanoma by transcriptomic profiling of fine needle biopsy specimens. J Mol Diagn 2006; 8:567-573.
Onken MD, Ehlers JP, Worley LA, Makita J, Yokota Y, Harbour JW. Functional gene expression analysis uncovers phenotypic switch in aggressive uveal melanomas. Cancer Res 2006; 66:4602-4609.
Harbour JW. Eye cancer: unique insights into oncogenesis: the Cogan Lecture. Invest Ophthalmol Vis Sci. 2006; 47:1736-1745.
Sun Y, Tran BN, Worley LA, Delston RB, Harbour JW. Functional analysis of the p53 pathway in response to ionizing radiation in uveal melanoma. Invest Ophthalmol Vis Sci 2005; 46:1561-1564.
Loercher AE, Tank EM, Delston RB, Harbour JW. MITF links differentiation with cell cycle arrest in melanocytes by transcriptional activation of INK4A. J Cell Biol 2005; 168:35-40.
Onken MD, Worley LA, Ehlers JP, Harbour JW. Gene expression profiling in uveal melanoma reveals two molecular classes and predicts metastatic death. Cancer Res 2004; 64:7205-7209.
Ma D, Zhou P, Harbour JW. Distinct mechanisms for regulating the tumor suppressor and anti-apoptotic functions of Rb. J Biol Chem 2003; 278:19358-19366.
Harbour JW, Dean DC. The Rb/E2F Pathway: Emerging paradigms and expanding roles. Genes Dev 2000; 14:2393-2409.
Harbour JW, Dean DC. Rb function in cell-cycle regulation and apoptosis. Nature Cell Biol 2000; 2:65-67.
Zhang HS, Gavin M, Dahiya A, Postigo AA, Ma D, Luo RX, Harbour JW, Dean DC. Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF. Cell 2000; 101:79-89.
Harbour JW, Luo RX, Dei Santi A, Postigo AA, Dean DC. Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1. Cell 1999; 98:859-969.
Brantley MA, Harbour JW. Inactivation of retinoblastoma protein in uveal melanoma by phosphorylation of sites in the COOH-terminal region. Cancer Res 2000; 60: 4320-4323.
Harbour JW, Dean DC. Chromatin remodeling and Rb activity. Curr Opin Cell Biol 2000; 12: 685-689.
Harbour JW, Lai S-L, Whang-Peng J, Gazdar AF, Minna JD, Kay FJ: Abnormalities in structure and expression of the human retinoblastoma gene in SCLC. Science 1988; 241:353-357.
