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UID:20261009T1516Z-1791559019.2971-EO-63307-1@10.73.3.201
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DTSTAMP:20261019T112913Z
CREATED:20261009T151122Z
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DTSTART;TZID=America/Chicago:20261021T120000
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SUMMARY: Department of Neuroscience Seminar: Philip Williams\, PhD
DESCRIPTION: “Influence of Homeostatic Diversity on Neuronal Degeneration i
 n the Retina” Philip Williams\, PhD: Associate Professor\, Ophthalmology an
 d Visual Sciences WashU Medicine DATE: Oct 21\, 2026 TIME: 12:00 p.m.-1:00 
 p.m. PLACE: Neuroscience Research Building Auditorium\, 4370 Duncan Avenue\
 , St. Louis\, MO 63110 Neurodegeneration frequently involves neuron type-sp
 ecific differences in susceptibility. The cellular features that underlie t
 he […]
X-ALT-DESC;FMTTYPE=text/html: <h3 style="text-align: center\;"><strong>“Inf
 luence of Homeostatic Diversity on Neuronal Degeneration in the Retina”</st
 rong></h3><p><img class="size-medium wp-image-23051 aligncenter" src="https
 ://ophthalmology.wustl.edu/app/uploads/2019/01/DSC_2816-200x300.jpg" alt=""
  width="200" height="300" /></p><p><a href="https://ophthalmology.wustl.edu
 /people/philip-williams-phd/">Philip Williams\, PhD</a>: <strong>Associate 
 Professor\, Ophthalmology and Visual Sciences</strong><br /><strong>WashU M
 edicine</strong></p><div class="event-meta-item event-dates"><time datetime
 ="2026-10-21T12:00:00-05:00"><strong>DATE:</strong> Oct 21\, 2026</time></d
 iv><div class="event-meta-item event-time"><strong>TIME:</strong> 12:00 p.m
 .-1:00 p.m.</div><div class="event-meta-item event-time"><strong>PLACE:</st
 rong> Neuroscience Research Building Auditorium\, 4370 Duncan Avenue\, St. 
 Louis\, MO 63110</div><div></div><div class="event-meta-item event-time">Ne
 urodegeneration frequently involves neuron type-specific differences in sus
 ceptibility. The cellular features that underlie the survival potential of 
 individual neurons are complex and interacting. The Williams lab has establ
 ished retinal ganglion cells as a model system to study intrinsic differenc
 es in neurodegenerative susceptibility. Retinal ganglion cells are ideal fo
 r such studies since they are optically accessible\, easily targetable for 
 treatment\, and are represented by 45 distinct types in mice all with diffe
 rent resilience in the face of patient relevant neurodegeneration models. T
 o understand what homeostatic features drive survival or death outcomes in 
 degeneration\, the lab has developed a pipeline of chronic genetically enco
 ded biosensor imaging to track diversity of cellular traits in homeostasis\
 , how these features correlate with survival outcome\, and what aberrant dy
 namics might drive degeneration. This observational pipeline is combined wi
 th pharmacological and gene therapy treatments to validate role of intrinsi
 c sates on survival and to potentially develop new therapies to prevent vis
 ion loss in clinically relevant disease models.</div>
LOCATION:Neuroscience Research Building Auditorium
GEO:38.635567;-90.255115
ORGANIZER;CN="Katherine":MAILTO:fitzpatrick@wustl.edu
URL;VALUE=URI:https://ophthalmology.wustl.edu/calendar/event/department-of-
 neuroscience-seminar-philip-williams-phd/
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DTSTART:20260308T080000
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