Andley Lab

Usha Andley, PhD, Professor, Ophthalmology & Visual Sciences

Dr. Andley’s profile

Research Interests

  • Role of chaperones in regulating protein homeostasis
  • Anti-cataract strategies that specifically target protein aggregation
  • The effects of protein aggregation on gene expression and cataract development
  • Autophagy and misfolded proteins in models of human congenital cataracts
  • Regulation of lens epithelial and fiber cell functions by crystallins

Current Projects

  • Investigating the mechanisms underlying cataract development in models of human hereditary cataracts, and correlating clinical cataract phenotype to markers of pathology
  • Analyzing the in vivo substrates of the molecular chaperones in the lens using knock-in mice expressing mutations associated with human cataracts
  • Examining the transcriptome changes in lenses associated with cataract development
  • Developing strategies to reduce lens opacification using small molecules in vivo
  • Developing blind and randomized trials in animal models to test efficacy of topical drug therapies to delay or reverse cataracts

Publications

View Usha Andley’s NCBI publications on PubMed»

Selection of articles and book chapters

Review articles:

Andley UP. The effect of alpha-crystalin in lens cell function and cataract pathology. Current Molecular Medicine, 2009. 9: 887-92.           

Andley UP. Cells in Focus. The lens epithelium: focus on the expression and function of the alpha-crystallin chaperones. International Journal of Biochemistry and Cell Biology, 2008, 40, 317-323.

Andley UP.  Crystallins in the Eye: Function and Pathology.  Progress in Retinal and Eye Research 2007; 26: 78-98.

Andley UPCrystallins and hereditary cataract: Molecular mechanisms and potential for therapy.  Expert Reviews in Molecular Medicine 2006; 8: 1-19.2.      

Andley UP, Chylack LT Jr.  Recent studies on photodamage to the eye with special reference to clinical phototherapeutic procedures.  Photoderm Photoimmunol Photomed 1990; 7:98-105.

Andley UP.  Photodamage to the eye.  Photochem Photobiol 1987; 46:1057-1066.

Book Chapters

Andley UP. Alpha-crystallins (HspB4 and HspB5) and cataract diseases. Chapter 2.2. In: Small Stress Proteins and Human Diseases, Edited by A-P Arrigo and S.Simon, Nova Science Publishers Inc, NY, USA, 2011, pp. 245-262.

Andley UP.  Ocular lens photobiology.  In Coohill T, Valenzeno DP (eds).  Photobiology for the 21st Century.  Overland Park, Kansas: Valdenmar Publishing Co, 2001, pp 135-141.

Andley UP, Liang JN, Lou MF.  Biochemical mechanisms of age-related cataracts.  IN Albert DM, Jakobiec FA (eds).  Principles and Practice of Ophthalmology: Clinical Practice.  Vol 2, Chapter 102, 2nd edition.  Philadelphia: WB Saunders, 1999, pp 1428-1449.      

Andley UP.  Biochemistry of the crystalline lens:  photo-oxidative stress.  IN Albert DM, Jakobiec FA (eds).  Principles and Practice of Ophthalmology: Clinical Practice.  Vol 1, Chapter 40.  Philadelphia: WB Saunders, 1994, pp 575-590.