Andley Lab

Usha Andley, PhD, Professor, Ophthalmology & Visual Sciences

Dr. Andley’s profile

Research Interests

  • Role of chaperones in regulating protein homeostasis
  • Anti-cataract strategies that specifically target protein aggregation
  • The effects of protein aggregation on gene expression and cataract development
  • Autophagy and misfolded proteins in models of human congenital cataracts
  • Regulation of lens epithelial and fiber cell functions by crystallins

Current Projects

  • Investigating the mechanisms underlying cataract development in models of human hereditary cataracts, and correlating clinical cataract phenotype to markers of pathology
  • Analyzing the in vivo substrates of the molecular chaperones in the lens using knock-in mice expressing mutations associated with human cataracts
  • Examining the transcriptome changes in lenses associated with cataract development
  • Developing strategies to reduce lens opacification using small molecules in vivo
  • Developing blind and randomized trials in animal models to test efficacy of topical drug therapies to delay or reverse cataracts

Publications

View Usha Andley’s NCBI publications on PubMed»