This Research Insight covers a publication from the Bassnett Lab. Here, we highlight how findings by Pooja Rathaur, PhD and colleagues have contributed to our understanding of how the fibrous molecules that comprise the zonular fibers of the eye support vision. In their paper published in Cells, scientists in the lab of Steven Bassnett, PhD—professor […]
This Research Insight covers a study from the Kerschensteiner Lab. Here, we highlight how Florentina Soto, PhD and colleagues characterized the functional properties of the output cells of the retina to understand how information is coded in the human retina. This study from the Kerschensteiner Lab, published in Neuron, marks the first functional characterization of […]
This Research Insight covers a publication from the Williams Lab. Here, we highlight how Allison Hall and colleagues unveiled the cellular identity of a retinal ganglion cell that innately survives well following injury to the optic nerve. They further explored cellular factors that could help explain the resilience of these cells to offer insights into […]
This Research Insight covers a study from the Chen Lab. Here, we highlight a proposed model for retinal degeneration based on binding activity of the Cone-Rod Homeobox transcription factor, CRX. In this study published in eLife, researchers in the lab of Shiming Chen, PhD, Dr. Bernard and Janet R. Becker Distinguished Professor of Ophthalmology at […]
This Research Insight covers a series of studies supported by Mae Gordon, PhD and Michael Kass, MD that highlights the impact of a long-term clinical study, the Ocular Hypertension Treatment Study (OHTS). Together, this research—spanning more than 20 years—has revolutionized the diagnosis of primary open-angle glaucoma (POAG), its treatment, and patient outcomes. In this series […]
This Research Insight covers a collaborative study pioneered by the Yoshimatsu Lab, which elucidates a rod photoreceptor-driven pathway in the zebrafish retina that supports dim-light vision and is shared across species. Whereas the rod pathway has been speculated to be unique to the mammalian retina, this study presents the first converging evidence that a homologous […]
This Research Insight covers a publication from the Kerschensteiner Lab. Here, we highlight how Michael Fitzpatrick, PhD and colleagues uncovered a new pupil response in the mouse, disentangled the neural pathway in the retina that drives it, and discovered that it is also present in humans. These findings shed new light on strategies the visual […]
This Research Insight covers a recent publication from the Siegfried Lab. Here, we highlight how Ying-Bo Shui, MD, PhD and colleagues identified a gene that might exacerbate the worse primary open-angle glaucoma presentation experienced by Black individuals. In their recent paper published in Scientific Reports, scientists in the lab of Carla Siegfried, MD, professor of […]
This Research Insight covers a recent publication from the Apte Lab. Here, we highlight how Ryo Terao, MD, PhD, Mitsukuni Yoshida, MD, PhD, and colleagues explore how excessive cholesterol accumulation in the retina contributes to the degeneration of light-sensing photoreceptors, leading to vision loss. The evidence presented in this study suggests that targeting a process […]
This Research Insight covers a recent publication from the Kerschensteiner Lab. Here, we highlight how Jenna Krizan, PhD and colleagues added clarity to an ongoing debate about the origin of direction-selective signaling in the brain and explored its role in the predatory behaviors of the mouse. In their recent paper published in PNAS, scientists in […]
This Research Insight covers a recent publication from the Morgan Lab. Here, we highlight the stand-out performance of a modified deep learning-based tool to assess the quality of electron micrographs in real-time. In their recent paper published in Microscopy and Microanalysis, scientists in the lab of Joshua Morgan, PhD, assistant professor of ophthalmology at WashU […]