Corneal Cross-linking for Adults

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Washington University Ophthalmologists now offer outpatient corneal collagen crosslinking therapy for adults. Corneal collagen cross-linking is an innovative treatment for keratoconus and certain corneal ectatic disorders. Keratoconus is a progressive eye condition that causes the cornea to thin and bulge, leading to vision distortion and impairment. Collagen cross-linking, or CXL, offers hope to individuals affected by this condition by halting its progression and improving visual outcomes.

What is corneal cross-linking (CXL) and how does it work? 

Collagen cross-linking is an innovative treatment that aims to halt the progression of keratoconus and improve visual outcomes. It is a minimally invasive procedure that involves the application of a photosensitizing agent called riboflavin to the cornea, followed by exposure to ultraviolet light. This combination helps strengthen the collagen fibers in the cornea, enhancing its structural integrity.

What is keratoconus and who is at risk?

Keratoconus is an eye condition characterized by the thinning and bulging of the cornea, which is the clear, dome-shaped surface that covers the front of the eye. This abnormal shape of the cornea can cause distorted vision, nearsightedness, and astigmatism.

While the exact cause of keratoconus is not yet fully understood, various factors are associated with an increased risk of developing the condition.

These risk factors include:

• Genetic Predisposition: Keratoconus may run in families, suggesting a genetic component to its development. If you have a close family member with keratoconus, your risk of developing it may be higher.
• Eye Rubbing: Frequent and vigorous eye rubbing is believed to contribute to the development and progression of keratoconus. Rubbing the eyes excessively can lead to thinning of the cornea and increase the risk of progression.
• Atopic Diseases: Certain allergic or atopic conditions, such as asthma, eczema, and hay fever, have been linked to an increased risk of keratoconus. The exact relationship between these diseases and keratoconus is not fully understood.
• Connective Tissue Disorders: Some connective tissue disorders, such as Ehlers-Danlos syndrome, Marfan syndrome, and Down syndrome, have been associated with a higher risk of developing keratoconus.
• Chronic Eye Irritation: Chronic eye inflammation or irritation, such as from long-term contact lens wear, can potentially contribute to the development of keratoconus.

It is important to note that having one or more of these risk factors does not guarantee that someone will develop keratoconus. Conversely, individuals without any apparent risk factors can also develop the condition. If you experience symptoms such as blurred or distorted vision, sudden changes in your prescription, or increased sensitivity to light, it is important to consult with an eye care professional for an accurate diagnosis and appropriate management.