Margolis Lab

Todd P. Margolis, MD, PhD, Alan A. and Edith L. Wolff Distinguished Professor and Chairman, Ophthalmology and Visual Sciences

Research

The primary focus of the Margolis laboratory is research on the cellular and molecular mechanisms that regulate the establishment and maintenance of latent neuronal infection with herpes simplex virus (HSV). Ongoing research is aimed at documenting the role of both neuronal and viral gene expression in the establishment and maintenance of HSV latency. The ultimate goal of this work is to gain enough of an understanding about the regulation of HSV latent infection that therapeutic interventions can be devised to eliminate latent infection or prevent viral reactivation. A second line of investigation focuses on development and evaluation of molecular diagnostics for infectious eye disease. A third line of investigation focuses on the use of telemedicine to screen AIDS patients for CMV retinitis in developing countries.

Publications

Click to view all Dr. Margolis NCBI publications on PubMed»

  1. Yen M, Ausayakhun S, Chen J, Ausayakhun S, Jirawison C, Heiden D, Holland GN, Margolis TP, Keenan JD. Telemedicine Diagnosis of Cytomegalovirus Retinitis by Nonophthalmologists. JAMA Ophthalmol. 2014 Jun 19.
  2. Culican SM, Rupp JD, Margolis TP. Retaining clinician-scientists: nature versus nurture. Invest Ophthalmol Vis Sci. 2014 May 27;55(5):3219-22.
  3. Maamari RN, Keenan JD, Fletcher DA, Margolis TP. A mobile phone-based retinal camera for portable wide field imaging. Br J Ophthalmol. 2014 Apr;98(4):438-41.
  4. Greene JB, Jeng BH, Fintelmann RE, Margolis TP. Oral azithromycin for the treatment of meibomitis. JAMA Ophthalmol. 2014 Jan;132(1):121-2.
  5. Estopinal CB, Ausayakhun S, Ausayakhun S, Jirawison C, Joy Bhosai S, Margolis TP, Keenan JD. Access to ophthalmologic care in Thailand: a regional analysis. Ophthalmic Epidemiol. 2013 Oct;20(5):267-73.
  6. Kempen JH, Sugar EA, Jaffe GJ, Acharya NR, Dunn JP, Elner SG, Lightman SL, Thorne JE, Vitale AT, Altaweel MM; Multicenter Uveitis Steroid Treatment (MUST) Trial Research Group. Fluorescein angiography versus optical coherence tomography for diagnosis of uveitic macular edema. Ophthalmology. 2013 Sep;120(9):1852-9.
  7. Friedman DS, Holbrook JT, Ansari H, Alexander J, Burke A, Reed SB, Katz J, Thorne JE, Lightman SL, Kempen JH; MUST Research Group. Risk of elevated intraocular pressure and glaucoma in patients with uveitis: results of the multicenter uveitis steroid treatment trial. Ophthalmology. 2013 Aug;120(8):1571-9.
  8. Bertke AS, Ma A, Margolis MS, Margolis TP. Different mechanisms regulate productive herpes simplex virus 1 (HSV-1) and HSV-2 infections in adult trigeminal neurons. J Virol. 2013 Jun;87(11):6512-6.
  9. Heiden D, Margolis TP, Lowinger A, Saranchuk P. Eye exam with indirect ophthalmoscopy for diagnosis of disseminated tuberculosis in patients with HIV/AIDS. Br J Ophthalmol. 2013 May;97(5):668-9.
  10. Bertke AS, Apakupakul K, Ma A, Imai Y, Gussow AM, Wang K, Cohen JI, Bloom DC, Margolis TP. LAT region factors mediating differential neuronal tropism of HSV-1 and HSV-2 do not act in trans. PLoS One. 2012;7(12):e53281.