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Vladimir Kefalov, PhD publications

View all of Vladimir Kefalov’s NCBI publications on PubMed»

2016

  • Razafsky D., Ward C., Potter C., Zhu W., Xue Y., Kefalov V.J., Fong L.G., Young S.G., Hodzic D. (2016) Lamin B1 and lamin B2 are long-lived proteins with distinct functions in retinal development. Mol Biol Cell 27:1928-37. PDF
  • Frederiksen R., Nymark S., Kolesnikov A.V., Berry J.D., Adler L., Koutalos Y., Kefalov V.J., Cornwall M.C. (2016) Rhodopsin kinase and arrestin binding control the decay of photoactivated rhodopsin and dark adaptation of mouse rods. J Gen Physiol. 148:1-11.Sato S, Kefalov VJ. (2016) PDF
  • SatoS., Kefalov V.J. cis Retinol oxidation regulates photoreceptor access to the retina visual cycle and cone pigment regeneration. J Physiol. 594:6753-6765. PDF
  • Sakurai K., Vinberg F., Wang T., Chen J., Kefalov V.J. (2016) The Na+/Ca2+, K+ exchanger 2 modulates mammalian cone phototransduction. Sci Rep 6:32521. doi: 10.1038/srep32521. PDF

2015

  • Berkowitz, B.A., Gorgis J., Patel, A., Baameur, F., Gurevich, V.V., Craft, C.M., Kefalov, V.J., Roberts, R. (2015) Development of an MRI biomarker sensitive to tetrameric visual arrestin 1 and its reduction via light-evoked translocation in vivo. FASEB J. 29:554-64. PDF
  • Xue, Y, Shen, S.Q., Jui, J, Rupp, A.C., Byrne, L.C., Hattar, S, Flannery, J.G, Corbo, J.C., Kefalov, V.J. (2015) CRALBP supports the mammalian retina visual cycle and cone vision. J Clin Invest 125:727-738. PDF
  • Tracy, C.M.*, Kolesnikov, A.V.*, Blake, D.R., Chen, C.-K., Baehr, W., Kefalov, V.J.#, Willardson, B.M.# (2015) Retinal cone photoreceptors require phosducin-like protein 1for G-protein complex assembly and signaling. PLoS One 10: doi: 10.1371/journal.pone.0117129. PDF
  • Sakurai K., Chen J., Khani S., Kefalov V.J. (2015) Regulation of mammalian cone phototransduction by recoverin and rhodopsin kinase. J Biol Chem 290:9239-9250. PDF
  • Zhang, N., Tsybovsky, Y., Kolesnikov, A.V., Rozanowska, M., Swider, M., Schwartz, S.B., Stone, E.M., Palczewska, G., Maeda, A., Kefalov, V.J., Jacobson, S.G., Cideciyan, A.V., Palczewski, K. (2015) Protein misfolding and the etiology of ABCA4-associated retinal degenerations. Hum Mol Genet 24:3220-3237. PDF
  • Vinberg, F., Kefalov, V.J. (2015) Simultaneous ex vivo functional testing of two retinas by in vivo electroretinogram system. JoVE 6: doi: 10.3791/52855. PDF
  • Sarria, I, Pahlberg, J, Cao, Y, Kolesnikov, A.V., Kefalov, V.J., Sampath, A.P., Martemyanov, K.A. (2015) Sensitivity and kinetics of signal transmission at the first visual synapse differentially impact visually-guided behavior. eLife 4: doi: 10.7554/eLife.06358. PDF
  • Vinberg, F., Wang, T., Molday, R.S., Chen, J., Kefalov, V.J. (2015) A new mouse model for stationary night blindness with mutant Slc24a1 explains the pathophysiology of the associated human disease. Hum Mol Genet 24:5915-29. PDF
  • Zhou, Z., Vinberg, F., Schottler, F., Doggett, T.A., Kefalov, V.J., Ferguson, T.A. (2015) Autophagy supports color vision. Autophagy 11:1821-32. PDF
  • Ruzycki, P.A., Tran, N.M., Kolesnikov, A.V., Kefalov, V.J., Chen, S. (2015) Graded gene expression changes determine phenotype severity in mouse models of CRX-associated retinopathies. Genome Biology 16: doi: 10.1186/s13059-015-0732-z. PDF
  • Berkowitz, B.A., Kern, T.S., Bissig, D, Patel, P, Bhatia, A, Kefalov, V.J., Roberts, R. (2015) Systemic retinaldehyde treatment corrects retinal oxidative stress, rod dysfunction and impaired visual performance in diabetic mice. Invest Ophthalmol Vis Sci 56:6294-303. PDF
  • Kolesnikov, A.V., Maeda, A., Tang, P.H., Imanishi, Y., Palczewski, K., Kefalov, V.J. (2015) Retinol dehydrogenase 8 and ATP-binding cassette transporter 4 modulate dark adaptation of M-cones in mammalian retina. J Phyiol 593:4923-41. PDF
  • Enright, J. M., Toomey, M.B., Sato, S., Temple, S.E., Allen, J., Nagy, L.D., Johnson, K.M., Xiao, Y., How, M.J., Johnson, S.L., Roberts, N., Kefalov, V.J., Guengerich, F. P., Corbo, J.C. (2015) Cyp27c1 Red-Shifts the Spectral Sensitivity of Photoreceptors by Converting Vitamin A1 into A2. Curr Biol [Epub ahead of print] PDF
  • Xue Y., Shen S.Q., Corbo J.C., Kefalov V.J. (2015) Circadian and light-driven regulation of rod dark adaptation. Sci Rep 5 doi:10.1038/srep17616 PDF

2014

  • Sakami, S., Kolesnikov, A.V., Kefalov, V.J., Palczewski, K. (2014) P23H opsin knock-in mice reveal a novel step in retinal rod disc morphogenesis.Hum Mol Genet 23:1723-1741. PDF
  • Sundermeier, T.R., Vinberg, F., Mustafi, D., Bai, X., Kefalov, V.J., Palczewski, K. (2014) R9AP overexpression alters phototransduction kinetics in iCre75 mice. Invest Ophthalmol Vis Sci 55, 1339-1347. PDF
  • Sundermeier, T.R., Zhang, N., Vinberg, F., Mustafi, D., Kohno, H., Golczak, M., Bai, X., Maeda, A., Kefalov, V.J., Palczewski, K. (2014) DICER1 is essential for survival of postmitotic rod photoreceptor cells in mice. FASEB J 28:3780-3791. PDF
  • Vinberg, F., Kolesnikov, A,V,, Kefalov, V.J. (2014) Ex Vivo ERG analysis of photoreceptors using an In Vivo ERG system. Vision Res 101C:108-117. PDF
  • Wang, J.S., Nymark, S., Frederiksen, R., Estevez, M.E., Shen, S.Q., Corbo, J.C., Cornwall, M.C., Kefalov, V.J. (2014) Chromophore supply rate-limits mammalian photoreceptor dark adaptation. J Neurosci 34:11212-11221. PDF
  • Palczewska, G., Vinberg, F., Stremplewski, P., Bircher, M.P., Salomǁ, D., Komar, K., Zhang, J., Cascella, M.#, Wojtkowski, M.#, Kefalov, V.J.#, Palczewski, K.# (2014) Human infrared vision is triggered by two-photon chromophore isomerization. Proc Natl Acad Sci USA 111:E5445-54. PDF

2013

  • Zhang, N., Kolesnikov, A.V., Jastrzebska, B., Mustafi, D., Sawada, O., Maeda, T., Genoud, C., Engel, A., Kefalov, V.J., Palczewski, K. (2013). Knock-in E150K opsin mutant mice, a model for autosomal recessive retinitis pigmentosa, exhibit structural disorganization of photoreceptor internal membranes. J Clin Invest 123, 121-137. PDF
  • Montana, C.L., Kolesnikov, A.V., Shen, S.Q., Myers, C.A., Kefalov, V.J., Corbo, J.C. (2013) Reprogramming of adult rod photoreceptors prevents retinal degeneration. Proc Natl Acad Sci USA 110, 1732-1737. PDF
  • Lai, C.W., Kolesnikov, A.V., Frederick, J.M., Blake, D.R., Jiang, L., Stewart, J.S., Chen, C.-K., Barrow, J.R., Baehr, W., Kefalov, V.J., Willardson, B.M. (2013) Phosducing-like protein 1 is essential for G protein assembly and signaling in retinal rod photoreceptors. J. Neurosci 33:7941-51. PDF
  • Deng, W.T., Sakurai, K., Kolandaivelu, S., Kolesnikov, A.V., Dinculescu, A., Li, J., Zhu, P., Liu, X., Pang, J., Chiodo, V.A, Boye, S.L., Chang, B., Ramamurthy, V., Kefalov, V.J., Hauswirth, W.W. (2013) Cone phosphodiesterase 6α’ restores rod function and confers distinct physiological properties in the rod phosphodiesterase 6β-deficient rd10 mouse. J Neurosci 33:11745-53. PDF
  • Cain, M.D., Vo, B.Q., Kolesnikov, A.V., Kefalov, V.J., Culican, S.M., Kerschensteiner, D., Blumer, K.J. (2013) An allosteric regulator of R7-RGS proteins influences light-evoked activity and glutamatergic waves in the inner retina. PLoS One 8:e82276. PDF

2012

  • Kefalov, V.J. (2012). Rod and cone visual pigments and phototransduction through pharmacological, genetic, and physiological approaches. J Biol Chem 287, 1635-1641. PDF
  • Lomonosova, E., Kolesnikov, A.V., Kefalov, V.J., Kisselev, OG. (2012) Signaling states of rhodopsin in rod disk membranes lacking transducin ßγ-complex. Invest Ophthalmol Vis Sci. 53, 1225-1233. PDF
  • Kolesnikov, A.V., Kefalov, V.J., (2012). Transretinal ERG recordings from mouse retina: rod and cone photoresponses. J Vis Exp 61, pii: 3424, doi: 10.3791/3424. PDF
  • Molnar, T., Barabas, P., Birnbaumer, L., Punzo, C., Kefalov, V.J., Krizaj, D. (2012). Store-operated channels regulate intracellular calcium in mammalian rods. J. Physiol 590, 3465-3481. PDF

2011

  • Wang, J.S. and Kefalov, V.J. (2011). The cone-specific visual cycle. Prog Retin Eye Res 30, 115-128. PDF
  • Parker, R., Wang, J.S., Kefalov, V.J., Crouch, R.K. (2011). Interphotoreceptor Retinoid-Binding Protein as the Physiologically Relevant Carrier of 11-cis-Retinol in the Cone Visual Cycle. J Neurosci 31, 4714-4719. PDF
  • Sakurai, K., Young, J.E., Kefalov, V.J. #, Khani, S.C. # (2011). Variation in rhodopsin kinase expression alters the dim flash response shut off and the light adaptation in rod photoreceptors. Invest Ophthalmol Vis Sci. 52, 6793-6800. PDF
  • Kolesnikov, A.V., Rikimaru, L., Hennig, A.K., Lukasiewucz, P.D., Fliesler, S., Govardovskii, V.I., Kefalov.#, V.J., Kisselev, O.G. #, (2011). G-protein ßγ-complex is critical for efficient signal amplification in vision. J Neurosci 31, 8067-8077. PDF
  • Kolesnikov, A.V., Tang, P.H., Parker, R.O., Crouch, R.K., Kefalov, V.J., (2011). The mammalian cone visual cycle promotes M/L-cone pigment regeneration independently of the interphotoreceptor retinoid-binding protein. J Neurosci 31, 7900-7909. PDF
  • Sakurai, K., Chen, J., Kefalov, V.J., (2011). Role of guanylyl cyclase modulation in mouse cone phototransduction. J Neurosci 31, 7991-8000. PDF

2010

  • Whitcomb, T.L., Sakurai, K., Brown, B.M., Young, J.E., Sheflin, L., Dlugos, C., Craft, C.M., Kefalov, V.J., Khani, S.C. (2010). Effect of G protein-coupled receptor kinase 1 (Grk1) overexpression on rod photoreceptor cell viability. Invest Ophthalmol Vis Sci 51:1728-1737. PDF
  • Wang, J. and Kefalov, V.J. (2010). Single-cell suction recordings from mouse cone photoreceptors. J Vis Exp 35, doi: 10.3791/1681. PDF
  • Fan*, J., Sakurai*, K., Crouch, R. K., Chen, C.-K., Rohrer, B., Wu, B. X., Yau, K.-Y., Kefalov, V. J., Crouch, R. K. (2010). Deletion of GRK1 causes retina degeneration through a transducin-independent mechanism. J. Neurosci 30:2496-2503. PDF
  • Cao, Y., Kolesnikov, A.V., Masuho, I., Kefalov, V.J., Martemyanov, K.A. (2010). Membrane anchoring subunits specify selective regulation of RGS9.Gbeta5 GAP complex in photoreceptor neurons. J Neurosci 30, 13784-13793. PDF
  • Kolesnikov, A.V., Fan, J., Crouch, R.K., Kefalov, V.J. (2010). Age-related deterioration of rod vision in mice. J Neurosci 30, 11222-11231. PDF
  • Kefalov, V.J., Cornwall, M.C., Fain, G.L. (2010). Physiological studies of the interaction between opsin and chromophore in rod and cone visual pigments. Methods Mol Biol. 652:95-114. PDF

2009

  • Wang, J., Estevez, M.E., Cornwall, M.C., Kefalov, V.J. (2009). Intra-retinal visual cycle required for rapid and complete cone dark adaptation. Nature Neuroscience 12:295-302. (Journal Cover). PDF
  • Yamashita, T., Liu, J., Gao, J., LeNoue, S., Wang, C., Kaminoh, J., Bowne, S.J., Sullivan, L.S., Daiger, S.P., Zhang, K., Fitzgerald, M.E., Kefalov, V.J., Zuo, J. (2009). Essential and synergistic roles of RP1 and RP1L1 in rod photoreceptor axoneme and retinitis pigmentosa. J. Neurosci 29:9748-9760. PDF
  • Wang, J. and Kefalov, V.J. (2009). An alternative pathway mediates the mouse and human cone visual cycle. Current Biology 19:1665-1669. PDF
  • Deng, W., Sakurai, K., Liu, J., Dinculescu, A., Li, J., Pang, J., Min, S., Chiodo, V., Boye, S., Chang, B., Kefalov, V.J., Hauswirth, W. (2009). Functional interchangeability of rod and cone transducin α-subunits. Proc Natl Acad Sci USA 106:17681-17686. PDF

2008

  • Fu*, Y., Kefalov*, V.J., Luo* D.-G., Xue*, T., Yau, K.-W. (2008). Quantal noise from human red cone pigment. Nature Neuroscience 11:565-571. PDF

2007

  • Shi, G., Yau, K.-W., Chen, J., Kefalov, V.J. (2007). Signaling properties of a short-wave cone visual pigment and its role in phototransduction. J. Neurosci 27:10084-10093. PDF
  • Imai*, H., Kefalov*, V.J., Sakurai*, K., Chisaka, O., Ueda, Y., Onishi, A., Morizumi, T., Fu, Y., Ichikawa, K., Nakatani, K., Honda, Y., Chen, J., Yau, K.-W., Shichida, Y. (2007). Molecular properties of rhodopsin and rod function. J Biol Chem 282:6677-6684. PDF

(* equal contribution; # co-corresponding author)