Siegfried Lab

Carla Siegfried, MD, Jacquelyn E. and Allan E. Kolker, MD, Distinguished Professor of Ophthalmology and Visual Sciences

Research

Glaucoma

Given the racial disparities of glaucoma prevalence, increased severity and vision loss, more rapid progression and earlier onset in African Americans, our lab studies the basic physiology of the trabecular meshwork, specialized cells that regulate intraocular pressure, the most important and only modifiable risk factor of glaucoma. By improving our understanding of these fundamental mechanisms of the disease, we hope to identify future novel therapies that will benefit patients.

Funding

Our work is funded through grants from the National Eye Institute of the NIH. We also receive support from unrestricted grants from Research to Prevent Blindness.

Publications

View all Carla Siegfried’s NCBi publications on PubMed

Intraocular Oxygen and Antioxidant Status: New Insights on the Effect of Vitrectomy and Glaucoma Pathogenesis Siegfried, C. J. & Shui, Y. B., Jul 2019, In : American journal of ophthalmology. 203, p. 12-25 14 p.

Setting the Gold(en) Standard for Ethical Care: #PatientCommunication Siegfried, C. J., Mar 2019, In : Ophthalmology. 126, 3, p. 335-337 3 p.

Monitoring Neurodegeneration in Glaucoma: Therapeutic Implications Ban, N., Siegfried, C. J. & Apte, R. S., Jan 2018, In : Trends in Molecular Medicine. 24, 1, p. 7-17 11 p.

Effects of vitrectomy and lensectomy on older rhesus macaques: Oxygen distribution, antioxidant status, and aqueous humor dynamics Siegfried, C. J., Shui, Y. B., Tian, B., Nork, T. M., Heatley, G. A. & Kaufman, P. L., Aug 2017, In : Investigative Ophthalmology and Visual Science. 58, 10, p. 4003-4014 12 p.

GDF15 is elevated in mice following retinal ganglion cell death and in glaucoma patients Ban, N., Siegfried, C. J., Lin, J. B., Shui, Y. B., Sein, J., Pita-Thomas, W., Sene, A., Santeford, A., Gordon, M., Lamb, R., Dong, Z., Kelly, S. C., Cavalli, V., Yoshino, J. & Apte, R. S., May 4 2017, In : JCI Insight. 2, 9

Expression profiling of ascorbic acid-related transporters in human and mouse eyes Ma, N., Siegfried, C., Kubota, M., Huang, J., Liu, Y., Liu, M., Dana, B., Huang, A., Beebe, D., Yan, H. & Shui, Y. B., Jun 2016, In : Investigative Ophthalmology and Visual Science. 57, 7, p. 3440-3450 11 p.

Mitochondrial oxygen metabolism in primary human lens epithelial cells: Association with age, diabetes and glaucoma Kubota, M., Shui, Y. B., Liu, M., Bai, F., Huang, A. J., Ma, N., Beebe, D. C. & Siegfried, C. J., Aug 1 2016, In : Free Radical Biology and Medicine. 97, p. 513-519 7 p.

Central corneal thickness correlates with oxygen levels in the human anterior chamber angle
Siegfried, C. J., Shui, Y. B., Bai, F. & Beebe, D. C., Mar 1 2015, In : American journal of ophthalmology. 159, 3, p. 457-462.e1

Impact of corneal endothelial dysfunctions on intraocular oxygen levels in human eyes
Huang, A. J. W., Shui, Y. B., Han, Y. P., Bai, F., Siegfried, C. J. & Beebe, D. C., Oct 2015, In : Investigative Ophthalmology and Visual Science. 56, 11, p. 6483-6488 6 p.

Mutation of the melastatin-related cation channel, TRPM3, underlies inherited cataract and glaucoma Bennett, T. M., Mackay, D. S., Siegfried, C. J. & Shiels, A., Aug 4 2014, In : PloS one. 9, 8, e104000.

Preserve the (intraocular) environment: The importance of maintaining normal oxygen gradients in the eye Beebe, D. C., Shui, Y. B., Siegfried, C. J., Holekamp, N. M. & Bai, F., May 2014, In : Japanese Journal of Ophthalmology. 58, 3, p. 225-231 7 p.

Randomized, prospective, comparative trial of ex-press glaucoma filtration device versus trabeculectomy (XVT Study) Netland, P. A., Sarkisian, S. R., Moster, M. R., Ahmed, I. I. K., Condon, G., Salim, S., Sherwood, M. B. & Siegfried, C. J., Feb 2014, In : American journal of ophthalmology. 157, 2, p. 433-440.e3

Aqueous humor oxygen measurements Nguyen, A., Shui, Y. B., Zhang, Q., Beebe, D. C. & Siegfried, C. J., Oct 1 2013, In : Journal of Glaucoma. 22, 8, p. e23-e24

The development of a decision analytic model of changes in mean deviation in people with glaucoma: The COA model Kymes, S. M., Lambert, D. L., Lee, P. P., Musch, D. C., Siegfried, C. J., Kotak, S. V., Stwalley, D. L., Fain, J., Johnson, C. & Gordon, M. O., Jul 1 2012, In : Ophthalmology. 119, 7, p. 1367-1374 8 p.

Racial differences in ocular oxidative metabolism: Implications for ocular disease
Siegfried, C. J., Shui, Y. B., Holekamp, N. M., Bai, F. & Beebe, D. C., Jul 1 2011, In : Archives of Ophthalmology. 129, 7, p. 849-854 6 p.

Vitreoretinal influences on lens function and cataract Beebe, D. C., Holekamp, N. M., Siegfried, C. & Shui, Y. B., Apr 27 2011, In : Philosophical Transactions of the Royal Society B: Biological Sciences. 366, 1568, p. 1293-1300 8 p.