The Biostatistics and Bioinformatics Core (BBC) offers a collaborative service to help vision scientists take advantage of rapidly evolving data-driven technologies in genomics, proteomics, and data analytics.
Our team is available to assist at all stages of a project including planning, optimization, implementation, analysis, and interpretation. We routinely work with labs looking to perform new experiments or re-analyze previously published data.
We have expertise in generation and analysis of data from the following techniques among others:
- scRNA-seq
- bulk RNA-seq
- ATAC-seq
- Massively Parallel Reporter Assays (MPRA/CRE-seq)
- CRISPR screening
- Metagenomic profiling
Examples of projects to which we have recently contributed:
Shiau F, Ruzycki PA, Clark BS. A single-cell guide to retinal development: Cell fate decisions of multipotent retinal progenitors in scRNA-seq. Dev Biol. 2021 Jun 17;478:41-58. doi: 10.1016/j.ydbio.2021.06.005. Epub ahead of print. PMID: 34146533.
Ray TA, Cochran K, Kozlowski C, Wang J, Alexander G, Cady MA, Spencer WJ, Ruzycki PA, Clark BS, Laeremans A, He MX, Wang X, Park E, Hao Y, Iannaccone A, Hu G, Fedrigo O, Skiba NP, Arshavsky VY, Kay JN. Comprehensive identification of mRNA isoforms reveals the diversity of neural cell-surface molecules with roles in retinal development and disease. Nat Commun. 2020 Jul 3;11(1):3328. doi: 10.1038/s41467-020-17009-7. PMID: 32620864; PMCID: PMC7335077.
Brodie-Kommit J, Clark BS, Shi Q, Shiau F, Kim DW, Langel J, Sheely C, Ruzycki PA, Fries M, Javed A, Cayouette M, Schmidt T, Badea T, Glaser T, Zhao H, Singer J, Blackshaw S, Hattar S. Atoh7-independent specification of retinal ganglion cell identity. Sci Adv. 2021 Mar 12;7(11):eabe4983. doi: 10.1126/sciadv.abe4983. PMID: 33712461; PMCID: PMC7954457. Soto F, Tien NW, Goel A, Zhao L, Ruzycki PA, Kerschensteiner D. AMIGO2 Scales Dendrite Arbors in the Retina. Cell Rep. 2019 Nov 5;29(6):1568-1578.e4. doi: 10.1016/j.celrep.2019.09.085. PMID: 31693896; PMCID: PMC6871773
Meet the Biostatistics and Bioinformatics Core Team
Philip Ruzycki, PhD
Assistant Professor, Ophthalmology and Visual Sciences
- Email: p.ruzycki@nospam.wustl.edu
Dr. Ruzycki leads the Bioinformatics group