We are thrilled to announce the publication of a groundbreaking study titled “LXR/CD38 Activation Drives Cholesterol-Induced Macrophage Senescence and Neurodegeneration via NAD+ Depletion“, authored by Ryo Terao, MD, PhD; Mitsukuni Yoshida, MD, PhD; Rajendra Apte, MD, PhD; and colleagues from the Apte Lab. In this study, our researchers unveil critical molecular mechanisms linking dysregulated cholesterol […]
We are thrilled to announce Charles Pfeifer as the distinguished recipient of the highly acclaimed 2024 Dr. Philip Needleman Pharmacology Award. This honor is bestowed upon a graduating student who has exhibited exceptional accomplishments in the field of Pharmacology. Founded in 1991 by Ms. Sima Needleman in tribute to her husband’s unwavering dedication to scholarship […]
We are thrilled to share with you a remarkable article titled “Retinal Detachment: Causes, Diagnosis, and Treatment Options” co-authored by Rajendra S. Apte, MD, PhD. This enlightening study, published in the renowned journal Nature, explores the intricate details of retinal detachment, providing valuable insights into its causes, diagnosis methods, and available treatment options. In this […]
Graduate student Tim Lee from the Division of Biology and Biomedical Sciences (DBBS), working in collaboration with the Apte Lab, has published a new paper revealing a significant discovery in the realm of photoreceptor dysfunction. The research, titled “Identification of IMPDH as a Therapeutically Modifiable Target of AMP Kinase in Rod Photoreceptors,” sheds light on […]
Congratulations to MSTP Student Joseph Lin on Collaborative Breakthrough Publication in Cell Reports Medicine: Targeting cell-type-specific, choroid-peripheral immune signaling to treat age-related macular degeneration The Apte Lab is proud to announce the groundbreaking collaborative research publication by MSTP student Joseph Lin and the Ruzycki Lab. The study, published in Cell Reports Medicine, addresses age-related macular […]
Diabetic retinopathy, a major concern for individuals with diabetes, has long been associated with the risk of vision loss and blindness. This condition, driven in part by the actions of retinal immune cells known as microglia, takes a significant toll on those it affects. In a groundbreaking publication, Charles Pfeifer, PhD, from the laboratory of […]
Congratulations to Michael Kass, MD, Mae Gordon, PhD, and the Ocular Hypertension Study Group on their latest publication discussing their findings after 20 years of follow up! More than 20 years after the launch of a landmark clinical trial, follow-up examinations and analyses found that not all patients with elevated eye pressure need pressure-lowering treatment […]
“SARM1 depletion rescues NMNAT1-dependent photoreceptor cell death and retinal degeneration” Congratulations to Dr. Rajendra Apte, his lab and the Genetics Department on their recent publication in eLife. Rajendra Apte, PhD and his lab with the help of Jeffrey Milbrandt, MD, PhD, Aaron DiAntonio, MD, PhD, Hiroki Kakita, MD, PhD and Yo Sasaki, PhD, from the […]
Diabetes-related vision loss most often is blamed on blood vessel damage in and around the retina, but new research indicates that much of that vision loss may result from nerve cell injury that occurs long before any blood vessels are damaged. The finding — from scientists at Washington University School of Medicine in St. Louis — […]