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AMD Breakthrough: Uncovering Therapeutic Targets

Joseph Lin
MSTP Student Joseph Lin’s Research Reveals New Insights into Age-Related Macular Degeneration

Congratulations to MSTP Student Joseph Lin on Collaborative Breakthrough Publication in Cell Reports Medicine: Targeting cell-type-specific, choroid-peripheral immune signaling to treat age-related macular degeneration

The Apte Lab is proud to announce the groundbreaking collaborative research publication by MSTP student Joseph Lin and the Ruzycki Lab. The study, published in Cell Reports Medicine, addresses age-related macular degeneration (AMD), a leading cause of blindness.

In advanced stages of AMD, abnormal blood vessels develop from the choroid and grow underneath the retina, leading to vision loss. Lin and his colleagues utilized single-cell RNA sequencing to identify a network of interactions between choroidal and peripheral blood immune cells that are dysregulated in AMD. This breakthrough paves the way for delineating disease-relevant, therapeutically modifiable targets.

The bedside-to-bench study leverages human data from multiple tissues to identify disease-relevant pathways. Lin’s dedication to advancing our understanding of AMD has resulted in a significant contribution to the field.

The studies were partly supported by the National Institutes of Health, highlighting the importance of federal funding in advancing medical research. The findings open new avenues for developing targeted therapies to address AMD, offering hope to those affected by this debilitating condition.