In the ever-changing world of medical research, breakthroughs often emerge from the synergy of passion, intellect, and mentorship. One exciting project currently taking place in the Chen and Rajagopal Labs, where Isabella Gomes is set to embark on a groundbreaking journey!
Isabella recently received the Research to Prevent Blindness/Janssen Medical Student Eye Research Fellowship. This prestigious award supports her groundbreaking research on CRX-associated retinopathies. Her work focuses on developing a multiparameter-based grading system and high-throughput assays, aiming to uncover the mechanisms behind these complex conditions.
WashU Medical Student
MD Candidate ’25
Her Research
A key part of Isabella’s research involves studying genotype-phenotype correlations. This means she’ll look closely at how specific genetic mutations impact the function of CRX, a crucial regulatory gene in the retina. By using advanced molecular techniques, she hopes to reveal hidden links between genetic changes and the clinical symptoms of retinopathies.
Isabella will also use high-throughput reporter assays in mouse retinal models. These assays will help her understand the functional effects of CRX mutations. Her goal is to see how these genetic changes disrupt the normal regulatory functions of CRX, providing new insights into the development of these eye diseases.
Ultimately, Isabella’s research aims to improve our understanding of CRX-associated retinopathies and lead to better clinical treatments. By establishing clear parameters for evaluating the effects of different interventions, her work will contribute to the refinement of treatment protocols and help develop personalized therapies.
Congratulations to Isabella Gomes
Isabella’s dedication and potential have been recognized with the Research to Prevent Blindness/Janssen Medical Student Eye Research Fellowship. This award highlights her commitment to advancing ophthalmology and positions her as a future leader in the field. Her research will not only deepen our understanding of CRX-associated retinopathies but also guide future clinical trials and genetic studies.
About Isabella Gomes
Isabella Gomes (she/her), MPH, MA, is a rising fourth-year medical student and Class President of her cohort at Washington University in St. Louis. She is currently in her research year, working as a clinical study coordinator and research fellow in Dr. Shiming Chen’s lab, exploring the clinical manifestations of Cone-Rod Homeobox (CRX) mutations. Most recently, Isabella completed the ITVS pathway translation in vision science, a seminar series led by ophthalmology faculty at WashU, during which she learned about various animal and human models in vision sciences.
We eagerly anticipate the impactful contributions that Isabella Gomes will make in the field of ophthalmology. Her journey is a testament to the power of dedication, innovation, and the relentless pursuit of knowledge.