This Research Insight covers a study from the Chen Lab. Here, we highlight a proposed model for retinal degeneration based on binding activity of the Cone-Rod Homeobox transcription factor, CRX. In this study published in eLife, researchers in the lab of Shiming Chen, PhD, Dr. Bernard and Janet R. Becker Distinguished Professor of Ophthalmology at […]
Aaron Y. Lee, MD, MSCI, and team named Phase 1 finalists in the NIH S-Index Challenge for developing a novel metric to reward high-quality data sharing. St. Louis, MO — September 16, 2025 — We are excited to share that Aaron Y. Lee, MD, MSCI, Arthur W. Stickle Distinguished Professor and Chairman of the WashU Medicine […]
Study identifies critical role of epigenetic regulation in rod photoreceptor specification Ismael Hernández-Núñez, PhD, researcher in the Clark lab at WashU Medicine John F. Hardesty, MD Department of Ophthalmology & Visual Sciences, and his laboratory recently published “Active DNA demethylation upstream of rod-photoreceptor fate determination is required for retinal development”. The study uncovers how changes […]
St. Louis, MO – September 10, 2025 – WashU Medicine John F. Hardesty, MD, Department of Ophthalmology & Visual Sciences is spotlighting advances in corneal regeneration, offering new hope for patients living with vision impairment due to corneal scars and opacities. Corneal scars and opacities—often caused by trauma, infection, or chemical injury—are a leading cause […]
We are excited to announce that Takeshi Yoshimatsu, PhD has received his first R01 grant from the National Institutes of Health (NIH)! This prestigious five-year grant, which began on July 1, 2025, will support groundbreaking research titled: “Visual Feature Competition Between Central and Peripheral Retinal Pathways.” Why This Research Matters “Eye fixation is a critical […]
Autophagy Regulates Müller Glial Cell Inflammatory Activation A new study published in Investigative Ophthalmology & Visual Science highlights the critical role of autophagy—the body’s process of recycling proteins—in regulating inflammation within the retina. The research, led by Thomas Ferguson, PhD, and Philip Ruzycki, PhD, from the John F. Hardesty, MD, Department of Ophthalmology & Visual […]
This Research Insight covers a series of studies supported by Mae Gordon, PhD and Michael Kass, MD that highlights the impact of a long-term clinical study, the Ocular Hypertension Treatment Study (OHTS). Together, this research—spanning more than 20 years—has revolutionized the diagnosis of primary open-angle glaucoma (POAG), its treatment, and patient outcomes. In this series […]
St. Louis, MO — August 27, 2025 — Researchers at the WashU Medicine John F. Hardesty, MD, Department of Ophthalmology & Visual Sciences in collaboration with the Department of Neurology have published new findings on the effects of sphingosine-1-phosphate (S1P) receptor modulation on the human retina. The study, led by the Apte Lab and published […]
We’re excited to share a new publication from Josh Morgan, PhD, Assistant Professor, Ophthalmology and Visual Sciences, titled “Alternative to the statistical mass confusion of testing for ‘no effect’”, published in the July 2025 issue of the Journal of Cell Biology. Morgan’s work challenges the traditional reliance on P values to determine whether an effect exists. While P […]
AUGUST 2025 – ST. LOUIS, MO — Brian Clark, PhD Assistant Professor, Ophthalmology and Visual Sciences, and colleagues have published a new study titled “Single-cell transcriptomics of ventral forebrain progenitors identifies Evf2 enhancer lncRNA–enhancer gene guidance through direct RNA binding and RNP recruitment domains”. This work provides new insights into how long non-coding RNAs (lncRNAs) […]
Science in Focus: Art Beyond the Microscope, a science as art competition! We invite all vision science researchers to participate in this unique competition, where science and art intersect to reveal the beauty within scientific research. Purpose and Goals Our goal is to celebrate the beauty of science and engage the community in its impact. […]
A Novel Insight Into Eye Immunity and Circadian Biology Charles Pfeifer, PhD, a former graduate student and postdoctoral researcher, Andrea Santeford, MS, supervisor in the Apte Lab at WashU Medicine, and Rajendra Apte, MD, PhD, Paul A. Cibis Distinguished Professor of Ophthalmology and Visual Sciences, have published a landmark study in the journal Glia. The paper, […]
JULY 3, 2025 — ST. LOUIS, MO — WashU Medicine John F. Hardesty, MD Department of Ophthalmology and Visual Sciences congratulates Mitsukuni Yoshida, MD, PhD, on being selected as a 2025 recipient of the NIH Outstanding Scholars in Neuroscience Award Program (OSNAP). I am very humbled and honored to receive this recognition. As a physician-scientist, […]
Groundbreaking Advances in Imaging Technologies and Machine Learning to Reanalyze OHTS Data | Leveraging Modern Techniques to Enhance Glaucoma Risk Assessment July 2, 2025 – St. Louis, MO: A new publication in JAMA Ophthalmology led by James C. Liu, MD, glaucoma specialist at WashU Medicine, highlights the transformative potential of deep learning and artificial intelligence […]
St. Louis, MO – June 18, 2025 – A recent study published in JAMA Ophthalmology sheds light on the correlation between the diagnosis of primary open-angle glaucoma (POAG) and the mental health decline in patients who were previously diagnosed with ocular hypertension. Conducted as part of the Ocular Hypertension Treatment Study, this research underscores the imperative […]
St. Louis, MO — May 30, 2025 — The John F. Hardesty, MD, Department of Ophthalmology and Visual Sciences at WashU Medicine proudly announces the winners of the 2025 Winston Fellow Competition. This annual event showcases outstanding research contributions from postdoctoral fellows and graduate students. We extend our heartfelt congratulations to the award recipients. Winners […]
ST. LOUIS, MO — May 27, 2025 — WashU Medicine Ophthalmology and Visual Science’s Rajendra S. Apte, MD, PhD, Paul A. Cibis Distinguished Professor and Vice Chair of Innovation and Translation, has been named the 2025 Snell Memorial Lecturer at the University of Rochester’s Flaum Eye Institute. Apte delivered his keynote address on May 23, […]
ST. LOUIS, MO — May 23, 2025 — The Foundation for Anesthesia Education and Research (FAER) has awarded a prestigious Research Fellowship Grant to Mitsukuni Yoshida, MD, PhD, a research fellow in the Apte Lab and a physician-scientist in the Academic Scholar Advancement Program (ASAP) in the Department of Anesthesiology. The funded project, titled “The […]
This Research Insight covers a collaborative study pioneered by the Yoshimatsu Lab, which elucidates a rod photoreceptor-driven pathway in the zebrafish retina that supports dim-light vision and is shared across species. Whereas the rod pathway has been speculated to be unique to the mammalian retina, this study presents the first converging evidence that a homologous […]
This Research Insight covers a publication from the Kerschensteiner Lab. Here, we highlight how Michael Fitzpatrick, PhD and colleagues uncovered a new pupil response in the mouse, disentangled the neural pathway in the retina that drives it, and discovered that it is also present in humans. These findings shed new light on strategies the visual […]