New Publication: Rethinking How We Quantify Effects in Cell Biology

New Publication: Rethinking How We Quantify Effects in Cell Biology

We’re excited to share a new publication from Josh Morgan, PhD, Assistant Professor, Ophthalmology and Visual Sciences, titled “Alternative to the statistical mass confusion of testing for ‘no effect’”, published in the July 2025 issue of the Journal of Cell Biology. Morgan’s work challenges the traditional reliance on P values to determine whether an effect exists. While P […]

Groundbreaking Study Reveals How lncRNA Evf2 Guides Forebrain Interneuron Development

Groundbreaking Study Reveals How lncRNA Evf2 Guides Forebrain Interneuron Development

AUGUST 2025 – ST. LOUIS, MO — Brian Clark, PhD Assistant Professor, Ophthalmology and Visual Sciences, and colleagues have published a new study titled “Single-cell transcriptomics of ventral forebrain progenitors identifies Evf2 enhancer lncRNA–enhancer gene guidance through direct RNA binding and RNP recruitment domains”. This work provides new insights into how long non-coding RNAs (lncRNAs) […]

Science in Focus: Art Beyond the Microscope

Science in Focus: Art Beyond the Microscope

Science in Focus: Art Beyond the Microscope, a science as art competition! We invite all vision science researchers to participate in this unique competition, where science and art intersect to reveal the beauty within scientific research. Purpose and Goals Our goal is to celebrate the beauty of science and engage the community in its impact. […]

First-of-Its-Kind Apte Lab Study Links Retinal Microglia to Circadian Rhythms

First-of-Its-Kind Apte Lab Study Links Retinal Microglia to Circadian Rhythms

A Novel Insight Into Eye Immunity and Circadian Biology Charles Pfeifer, PhD, a former graduate student and postdoctoral researcher, Andrea Santeford, MS, supervisor in the Apte Lab at WashU Medicine, and Rajendra Apte, MD, PhD, Paul A. Cibis Distinguished Professor of Ophthalmology and Visual Sciences, have published a landmark study in the journal Glia. The paper, […]

Yoshida Named 2025 NIH Outstanding Scholar in Neuroscience

Yoshida Named 2025 NIH Outstanding Scholar in Neuroscience

JULY 3, 2025 — ST. LOUIS, MO — WashU Medicine John F. Hardesty, MD Department of Ophthalmology and Visual Sciences congratulates Mitsukuni Yoshida, MD, PhD, on being selected as a 2025 recipient of the NIH Outstanding Scholars in Neuroscience Award Program (OSNAP). I am very humbled and honored to receive this recognition. As a physician-scientist, […]

Groundbreaking Advances in Imaging Technologies and Machine Learning Revolutionize the Ocular Hypertension Treatment Study (OHTS)

Groundbreaking Advances in Imaging Technologies and Machine Learning Revolutionize the Ocular Hypertension Treatment Study (OHTS)

Groundbreaking Advances in Imaging Technologies and Machine Learning to Reanalyze OHTS Data | Leveraging Modern Techniques to Enhance Glaucoma Risk Assessment July 2, 2025 – St. Louis, MO: A new publication in JAMA Ophthalmology led by James C. Liu, MD, glaucoma specialist at WashU Medicine, highlights the transformative potential of deep learning and artificial intelligence […]

Understanding the Impact of Glaucoma Diagnosis on Mental Health

Understanding the Impact of Glaucoma Diagnosis on Mental Health

St. Louis, MO – June 18, 2025 – A recent study published in JAMA Ophthalmology sheds light on the correlation between the diagnosis of primary open-angle glaucoma (POAG) and the mental health decline in patients who were previously diagnosed with ocular hypertension. Conducted as part of the Ocular Hypertension Treatment Study, this research underscores the imperative […]

WashU Medicine Celebrates the Winners of the 2025 Winston Fellow Competition

WashU Medicine Celebrates the Winners of the 2025 Winston Fellow Competition

St. Louis, MO — May 30, 2025 — The John F. Hardesty, MD, Department of Ophthalmology and Visual Sciences at WashU Medicine proudly announces the winners of the 2025 Winston Fellow Competition. This annual event showcases outstanding research contributions from postdoctoral fellows and graduate students. We extend our heartfelt congratulations to the award recipients. Winners […]

FAER Awards Research Fellowship Grant to Dr. Mitsukuni Yoshida

FAER Awards Research Fellowship Grant to Dr. Mitsukuni Yoshida

ST. LOUIS, MO — May 23, 2025 — The Foundation for Anesthesia Education and Research (FAER) has awarded a prestigious Research Fellowship Grant to Mitsukuni Yoshida, MD, PhD, a research fellow in the Apte Lab and a physician-scientist in the Academic Scholar Advancement Program (ASAP) in the Department of Anesthesiology. The funded project, titled “The […]

An Evolutionarily Conserved Pathway to Support Night Vision

An Evolutionarily Conserved Pathway to Support Night Vision

This Research Insight covers a collaborative study pioneered by the Yoshimatsu Lab, which elucidates a rod photoreceptor-driven pathway in the zebrafish retina that supports dim-light vision and is shared across species. Whereas the rod pathway has been speculated to be unique to the mammalian retina, this study presents the first converging evidence that a homologous […]

Evolutionarily Conserved Pupil Response Sharpens Image Quality to Improve Visual Acuity 

Evolutionarily Conserved Pupil Response Sharpens Image Quality to Improve Visual Acuity 

This Research Insight covers a publication from the Kerschensteiner Lab. Here, we highlight how Michael Fitzpatrick, PhD and colleagues uncovered a new pupil response in the mouse, disentangled the neural pathway in the retina that drives it, and discovered that it is also present in humans. These findings shed new light on strategies the visual […]

ARVO 2025 WashU Medicine Presenters

ARVO 2025 WashU Medicine Presenters

The 2025 ARVO Annual Meeting is the premier international forum for the exchange of cutting-edge research and ideas in the field of eye and vision science. Each year, thousands of scientists, clinicians, trainees, and professionals from affiliated disciplines convene to share their latest findings, foster collaborations, and shape the future of vision research. In 2025, […]

A Putative Role of SDPR in Primary Open-Angle Glaucoma 

A Putative Role of SDPR in Primary Open-Angle Glaucoma 

This Research Insight covers a recent publication from the Siegfried Lab. Here, we highlight how Ying-Bo Shui, MD, PhD and colleagues identified a gene that might exacerbate the worse primary open-angle glaucoma presentation experienced by Black individuals.  In their recent paper published in Scientific Reports, scientists in the lab of Carla Siegfried, MD, professor of […]

Rajendra Apte, MD, PhD receives Outstanding Faculty and Staff Award

Rajendra Apte, MD, PhD receives Outstanding Faculty and Staff Award

St. Louis, MO — April 21, 2025 — Rajendra Apte, MD, PhD, was honored with the Outstanding Faculty and Staff Award during a special ceremony recognizing exemplary contributions to the academic community. The 26th annual Outstanding Faculty and Staff Award Ceremony took place on Monday, April 21, at 5:00 p.m. in Steinberg Auditorium on the […]

A Causal Link Between Cholesterol Accumulation and Retinal Degeneration 

A Causal Link Between Cholesterol Accumulation and Retinal Degeneration

This Research Insight covers a recent publication from the Apte Lab. Here, we highlight how Ryo Terao, MD, PhD, Mitsukuni Yoshida, MD, PhD, and colleagues explore how excessive cholesterol accumulation in the retina contributes to the degeneration of light-sensing photoreceptors, leading to vision loss. The evidence presented in this study suggests that targeting a process […]

WashU Medicine Shines at NANOS 2025

NANOS 2025

St. Louis, MO — March 31, 2025 — WashU Medicine John F. Hardesty, MD, Department of Ophthalmology & Visual Sciences had a remarkable showing at the 2025 North American Neuro-Ophthalmology Society (NANOS) Annual Meeting in Tucson, AZ. NANOS, a leading organization dedicated to advancing knowledge, research, and training in neuro-ophthalmology, brings together experts from around […]

WashU Medicine Study Highlights Most Effective Treatments for Chronic Central Serous Chorioretinopathy

Treatments for Chronic Central Serous Chorioretinopathy

St. Louis, MO — April 1, 2025 —Researchers from WashU Medicine John F. Hardesty, MD Department of Ophthalmology and Visual Sciences have identified the most effective treatments for chronic central serous chorioretinopathy (CSCR), a condition that can cause blurry vision and vision loss. The study, led by Henok Getahun and Dr. Rajendra Apte, reviewed the […]

The Role of Direction-Selective Signaling in Predation

This Research Insight covers a recent publication from the Kerschensteiner Lab. Here, we highlight how Jenna Krizan, PhD and colleagues added clarity to an ongoing debate about the origin of direction-selective signaling in the brain and explored its role in the predatory behaviors of the mouse. In their recent paper published in PNAS, scientists in […]