Joseph Lin, MSTP Student in the Apte Lab has just published a paper in the Proceedings of the National Academy of Sciences (PNAS) entitled “Dry Eye Disease in Mice Activates Adaptive Corneal Epithelial Regeneration Distinct from Constitutive Renewal in Homeostasis” Joseph, along with additional faculty members of the Department of Ophthalmology and Visual Sciences discuss how through the studying of mice, they have found proteins made by stem cells that regenerate the cornea may be new targets for treating and preventing injuries in people with a condition known as dry eye disease, who are more likely than those with healthy eyes to suffer injuries to their corneas.
We conducted single-cell RNA sequencing to identify genes important to maintaining the health of the cornea, and we believe that a few of them particularly SPARC, may provide potential therapeutic targets for treating dry eye disease and corneal injury.
Joseph Lin, MD/PhD student, Apte Lab
To read full articles, click on links below:
“Dry Eye Disease Alters How the Eye’s Cornea Heals Itself After Injury”