Rajendra Apte, MD, PhD, Paul A. Cibis Distinguished Professor of Ophthalmology and Visual Sciences
Innate immunity and immune effector mechanisms in the retina; oxidative stress and cell death; models of developmental angiogenesis and neovascularization; inflammation and photoreceptor survival; macular degeneration
Ken Blumer, PhD, Professor, Cell Biology and Physiology
Currently our goals are to elucidate the mechanistic and physiological functions of RGS proteins in the cardiovascular, nervous and visual systems through biochemical, cell biological, genetic and physiologic studies of knockout and transgenic mice.
Andreas Burkhalter, PhD, Professor, Neuroscience
Our studies of the visual system in mice are aimed at understanding how the visual cortex is subdivided into different areas, how the network of connections between areas develops, how it is organized in the adult and how it is altered by visual experience. Interareal networks are important for visual perception and visually guided actions.
Shiming Chen, PhD, Professor, Ophthalmology and Visual Sciences Professor, Developmental Biology
The major goal of our laboratory research is to identify the molecular mechanism(s) regulating photoreceptor gene expression in the mammalian retina and the implications of these mechanisms for understanding photoreceptor degenerative diseases and developing therapeutic treatments for these diseases.
Joseph Corbo, MD, PhD, Associate Professor, Pathology & Immunology
We are interested in the transcriptional regulatory networks that underlie the development, evolution, and diseases of photoreceptors in the retina. We are taking a multi-disciplinary approach to the problem of how a network of transcription factors orchestrates the expression of distinct cohorts of downstream genes to build this complex micromachine, the photoreceptor cell.
Mae Gordon, PhD, Professor, Ophthalmology and Visual Sciences; Professor, Division of Biostatistics
Dr. Gordon works closely with the Vision Research Coordinating Center. The mission of the Vision Research Coordinating Center (VRCC) is to conduct pilot studies to provide a sound scientific foundation for more definitive larger studies to develop new outcome measures, to design and implement observational studies and clinical trials. The VRCC also serves as the coordinating center for two multi-center clinical studies funded by the National Institutes of Health.
Daniel Kerschensteiner, MD, Professor, Ophthalmology and Visual Sciences; Professor, Neuroscience; Professor, Biomedical Engineering
We would like to understand the principles that guide the assembly of neural circuits and to decipher the way they process information. Our efforts concentrate on the mammalian retina.
Todd P. Margolis, MD, PhD, Alan A. and Edith L. Wolff Distinguished Professor and Chairman, Ophthalmology and Visual Sciences
The primary focus of the Margolis laboratory is research on the cellular and molecular mechanisms that regulate the establishment and maintenance of latent neuronal infection with herpes simplex virus (HSV). Ongoing research is aimed at documenting the role of both neuronal and viral gene expression in the establishment and maintenance of HSV latency.
Lawrence Snyder, MD, PhD, Professor, Neuroscience
My laboratory studes how the brain, and especially the cerebral cortex, combines sensory information with higher order cognition (rules, memory, etc.) in order to drive motor commands. Much of our work is focused on spatial processing for guiding eye and arm movements.
Lawrence Tychsen, MD, John F. Hardesty, MD, Distinguished Professor of Ophthalmology and Visual Sciences; Professor, Neurobiology; Professor, Ophthalmology in Pediatrics, Dept of Pediatrics
Dr. Tychsen’s laboratory work is focused broadly on development of binocular vision in infant humans and monkeys, and specifically on neural mechanisms in strabismus (the clinical disorder of crossed-eyes)
Vladimir Kefalov, PhD publications